Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.

The work, published in the March 8 issue of Science, finally proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.

The paper shows all of the 117 drugs tested work on the single enzyme through a common mechanism. This means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer’s disease and type 2 diabetes.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says the lead author of the paper, Professor David Sinclair, from UNSW Medicine, who is based at Harvard University. “In effect, they would slow ageing.”
The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.

Although research surrounding resveratrol has been going for a decade, until now the basic science had been contested. Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer’s and Parkinson’s diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis (inflammatory bowel disease).

“In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” says Professor Sinclair, a geneticist with the Department of Pharmacology at UNSW.

From: University of New South Wales via EurekAlert
Published March 9, 2013 07:56 AM

Alzheimer’s Disease is a neurodegenerative disease that is characterized by accumulation of beta-amyloid and tau proteins in the brain.  Oleocanthal is a phenolic component found abundantly in extra-virgin olive oil Braggs Extra Virgin Olive Oil; some previous studies suggest that the compound may exert neuroprotective effects.  Amal Kaddoumi, from the University of Louisiana (Louisiana, USA), and colleagues completed in vitro and in vivo studies that demonstrate the ability for oleocanthal to two proteins- P-glycoprotein (P-gp) and LDL lipoprotein receptor related protein-1 (LRP1) – as well as key enzymes believed to be critical in removing beta-amyloid from the brain. The study investigators conclude that: “these findings provide experimental support that potential reduced risk of AD associated with extra-virgin olive oil could be mediated by enhancement of [beta-amyloid] clearance from the brain.”

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This facial massage technique is one of the best out there. As a massage therapist, I have tried this and am sold that it really does work to relax, tighten and strengthen your all to forgotten facials muscles. Most of us just go about our days and never really touch our face at all. Well, there are muscles there too that need attention and now you know what to do. Have fun on your way to looking younger and also feeling better.

Tanaka Face Massage Part 2

Japanese beauty expert, Yukuko Tanaka, presents her anti-aging, face contouring massage. This is an excellent routine to add to your skin care regimen, and will reduce wrinkles, prevent sagging skin, improve sagging skin, improve puffy eyes and under-eye bags and more.

Presented to you by http://www.EpicBeautyGuide.com
Your Guide to Getting & Staying Naturally Beautiful

It’s amazing to think that not that long ago the life expectancy was around 30 for most of the people on the planet. Momentum as definitely been on our side when it comes to longevity and this article supports that.

Human longevity has improved so rapidly over the past century that 72 is the new 30, scientists say.

Researchers at the Max Planck Institute for Demographic Research in Rostock, Germany, said progress in lowering the odds of death at all ages has been so rapid since 1900 that life expectancy has risen faster than it did in the previous 200 millennia since modern man began to evolve from hominid species.

The pace of increase in life expectancy has left industrialized economies unprepared for the cost of providing retirement income to so many for so long.

The study, published in the Proceedings of the National Academy of Sciences of the United States, looked at Swedish and Japanese men – two countries with the longest life expectancy today. It concluded that their counterparts in 1800 would have had lifespans that were closer to those of the earliest hunter-gatherer humans than they would to adult men in both countries today.

Those primitive hunter gatherers, at age 30, had the same odds of dying as a modern Swedish or Japanese man would face at 72.

The study did not try to draw conclusions about whether the extension of human life was moral or desirable, or whether it could occur without depleting the faculties needed to enjoy the extra years.

Instead, it tried to look at how the odds of dying at specific ages had changed over time. The researchers used longevity data from chimpanzees in captivity to estimate lifespans for pre-humans and data from modern day hunter-gatherer tribes as a benchmark for early human lifespans.

“The recent jumps in mortality reduction are remarkable in the context of mammal diversity because age-specific death rates for hunter-gatherers are already exceptionally low, probably among the lowest of any non-human primate,” the study noted.

In fact, the rate at which human life expectancy is rising is even faster than that achieved by scientists when they tried to breed organisms such as fruit flies to create genetically engineered long-living species. Although these experiments produced sharp rises in longevity, the rise in human longevity over the past century, which is not based on genetic improvements, has been much starker.

Mr Burger noted that the very rapid improvement in lifespans coincided with the invention of antibiotics and vaccines, huge improvements in agricultural efficiency that made food far more available and the widespread development of systems that made clean water more readily accessible.

Human mortality, he added, has shown itself to be far more “plastic” and capable of manipulation than anyone had imagined.

Norma Cohen
CNBC
Tue, 26 Feb 2013 12:55 CST

Source: Financial Times

This is an excellent all-natural cream that can be used every day. With so many anti-aging creams, nutrition supplements and new gadgets designed to – hopefully – make wrinkles disappear, it’s always great to see new innovation that is truly promising.

Anti-Aging Cream
By Nicole Roberts

Aging cannot be stopped on its tracks. But with proper skin care products and the right anti-aging cream, amazing results can be seen in just a few weeks. The results become more visible with regular use. It is advised though that when using anti-aging wrinkle cream, the entire kit of the same product must be used.

Anti-Aging Cream Kits

The facial skin has to be cleansed, toned, and moisturized. Although there are hundreds of products, there are a few that contain top-notch yet safe ingredients. A daily regimen of cleansing, toning, and moisturizing keeps wrinkles at bay. Unfortunately, some women do not start their skin care routine at a young age. Absence or lack of skin care causes irreversible skin damage and early skin aging. Fortunately, the right products can help reverse skin deterioration and revert old-looking skin to new fresh skin.

Anti-aging wrinkle cream kits usually come with a foaming cleanser, day moisturizer and night moisturizer, and a separate cream for the eye area. A complete kit has different products for different purposes but all of these works together to complement and enhance total performance.

A facial anti aging wrinkle cream has a different formulation from the eye cream, the eye area being more delicate than facial skin. Dark skin under the eyes is a common problem among women. The latest eye cream developed integrates the latest skin care technology that repairs and lightens the skin area under the eyes. Wrinkles, laughter lines, and crow’s feet can be visibly reduced in just a few weeks.

Follow the instructions carefully and do not miss a regime to get the best results as promised. Oftentimes, women have different reactions to the same product. While some may see the nice outcome in two weeks, others will have to wait two more weeks to see minimized fine lines and luminous skin.

Effective Ingredients

Activinol Technology is the secret to an excellent www.beautifulisageless.com anti-aging cream. This technology is awaiting its US patent. Activin is a substance that works to trigger and improve the skin’s self-repair system to create new skin, naturally. Other ingredients include the phytochemicals, amorphohallus and sesbania. Phytochemicals are chemical substances obtained from plants.

These substances in anti-aging creams are processed into a serum that aggressively induces the skin’s ability to repair itself. The results are dramatic. Statistics show that women who have used a product with activinol experienced “new” skin. Later, wrinkles are reduced and discolorations are lightened by 100%. Skin also feels tighter. The products should be used twice daily as indicated in the instructions.

Other products are firming creams to tighten “chicken skin” of the neck. Other anti-aging creams are prepared to combat deeper lines and sculpt the aging face to youthful curves. Antiaging wrinkle creams can be purchased online. Read through the different products and discover one that’s best for your skin and level of skin aging.

Learn more about anti-aging creams. Banish those wrinkles and discolorations. Get yourself a younger looking skin with an anti-aging wrinkle cream that works like magic. The next time you look into the mirror, see a familiar pretty face, a younger-looking you.

Nicole Roberts

Article Source: http://EzineArticles.com/?Anti-Aging-Cream&id=6026403 Anti-Aging Cream

Anti-aging is super popular these days. It seems more and more companies are coming out with the next new “ageless” remedy that’s going to turn back the hands of time. And though many of these products may very well make you look somewhat younger, they basically work with the physical “form” which is limited to – well, the physical form.

What I’m getting at here is simply this. If you want to slow down the aging process in your body then first you have to understand that the idea of aging is just a mind concept with an attached “definition” you have placed on it. And if you are like most human beings, your definition is really limited, e.g. you’re old and ready to die when you’re 80 or things like, the life expectancy is 76 or it’s natural to get sick and die when you get older or very few people ever make it to 100. While those ideas seem normal because for the most part they are true, what we have to ask ourselves is this: Are they true because they are true or are they true because we believe them to be true therefore we create them to be so? Something to think about.

BEING ALIVE.
Those simple words.
What do they mean?
Perhaps an opportunity:
To AWAKEN again to a new light day, to experience the “dance of ALIVEness” with all other alive creatures.

To BREATHE in deeply the invisible substance called air – air blowing through the planet, air that connects us all – the bringer of life itself to everything.

To SEE the magic in a simple flower soaking up the sun to become spectacular COLORS or an ant doggedly walking through that jungle called grass.
To witness the awesome FLIGHT of winged creatures zooming seemingly weightless through that invisible air.
To ponder the BLUE SKY and why it’s not green. Blue seems to match so perfectly.
To contemplate the clouds – the ever changing art on the canvas called sky.
To HEAR a billion different sounds playing out the greatest symphony ever written.
To TOUCH everything that surrounds you, fingertips registering to brain a million different textures, temperatures and sensations.
To SMELL the awesome ambiance of natures radiant aromas greeting you, guiding you, delighting you.
To TASTE the unending variety of Mother Natures life nurturing gifts she so freely offers.
To SHARE yourSELF with those you love and cohabitate the planet with.
To SMILE.
To LAUGH.
To CRY.
To feel LOVED.
To LOVE.
To LISTEN.
To WORK.
To PLAY.
TO GIVE.
To RECEIVE.
And perhaps, last but not least….
To say “thank you” …for BEING ALIVE another day.

So much to do. So simple.
Just BEING ALIVE is truly the GREATEST!

We come into this world free beings. But that doesn’t last long. Immediately we are given names, finger printed, documented, given an SS number and … of course, the countdown clock is started. We are given an age. Out lives will play out so much according to that age thing we were given. In fact, pretty much our entire lives will be massively affected by the “numbers” we become each year. But the truth is…we have no age. Age is nothing but a mind construct. It truly has no meaning other that the meaning we place on it. But then again that is true for everything.

So dump the idea of age and live free. Live as who you are at any given moment not who you have been told you are.